Understanding how informal enterprises are affected by the Covid-19 crisis is of central importance for identifying effective responses and designing support strategies that can encounter the socioeconomic impacts of the global pandemic. This document provides answers to a set of questions that address, for example, how governments and other actors can effectively reach out to informal economic units, the kind of support that is needed and what might be effective ways to reduce the risk of informalization of formal jobs and economic units. It is a living document that will be updated with additional practical insights on ongoing basis.